<h1>Sustainable Drug Delivery system to Treat Angina Effectively </h1>

Angina pectoris known as Angina is the sensation or pain in the chest due to ischemia of the heart muscle as a result of obstruction of the coronary arteries. Angina may lead to anemia, abnormal heart rhythm and heart failure. Angina is a leading cause for death during early 20^th century. Hypertension damages the heart vessels leading to blockage in the arteries, resulting in abnormal blood flow to the heart, which causes Angina or chest pain.

Conventional drug delivery system to treat Angina is not very effective as it is not reaching the affected site in an appropriate manner. The guarded therapeutic method of treating Angina and Hypertension is quite challenging as it regulate the drug release. Matrix system is often deployed to attain the expected results. Nifedipine as a matrix tablet is prepared using polymers is orally administered to get the desired effects. Formulation prepared with HPMC K100M showed 97% of drug release at 24 hrs and with Eudragit indicates 99% of drug release at 20 hrs release of Nifedipine drug.

Sustained release of drug is a modified form of dosage that sustains the therapeutic activity of the drug for a long time. In this method, it is possible to eliminate the delay and ensure immediate release of the drug, which in turn produces expected therapeutic effect. Sustained method follows a system of gradual yet sustained method of releasing additional drug over a period of predetermined time, eliminating the need for night dosage. It not only offers the best care to the patient by optimizing the Pharmacodynamics and Pharmacokinetic properties of a drug but also minimizes the side effects. It controls the alarming situation in a short time if it is administered in the most effective way.

Oral administration of the sustained drug delivery is generally preferred as it is easy and convenient to administer orally. It offers a great flexibility in designing the pill in the expected design and dosages in a cost effective manner.

Authors Rita B and Suresh V published these details in the ‘Annals of Clinical and Laboratory research ‘journal.